MOB1B_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: MOB1B , MOB4A, MOBKL1A
Protein names and data: MOB1B_HUMAN , MOB kinase activator 1B , Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A Lenght: 216 a.a.
Mass: 25091 Da
fasta formatted sequence
Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.

Database cross-references

UniProt: Q7L9L4
Ensembl: ENST00000309395
Ensembl: ENST00000396051
MIM: 609282
neXtProt: NX_Q7L9L4
Antibodypedia: Q7L9L4 (may not find the protein thus also not any antibody)
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