RBCC

MP2K3_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: MAP2K3 , MEK3, MKK3, PRKMK3, SKK2
Protein names and data: MP2K3_HUMAN , Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPKK 3; 2.7.12.2 , MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2 Lenght: 347 a.a.
Mass: 39318 Da
fasta formatted sequence
Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Disease: ( OMIM: 602315 ) Note=Defects in MAP2K3 may be involved in colon cancer.
Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Genetic variants

26 - 26 R -> T. VAR_040817
40 - 40 P -> T (in dbSNP:rs33911218). VAR_046062 33911218
55 - 55 R -> T (in dbSNP:rs36047035). VAR_061742 36047035
68 - 68 S -> P (in dbSNP:rs34105301). VAR_046063 34105301
84 - 84 A -> T (in dbSNP:rs2305873). VAR_046064 2305873
90 - 90 M -> I (in dbSNP:rs36076766). VAR_046065 36076766
94 - 94 R -> L (in dbSNP:rs56067280). VAR_046066 56067280
96 - 96 R -> W (in dbSNP:rs56216806). VAR_046067 56216806
175 - 175 R -> W (in colon cancer). VAR_014208
215 - 215 L -> V (in colon cancer). VAR_014209
293 - 293 R -> H (in dbSNP:rs35206134). VAR_046068 35206134
339 - 339 V -> M (in dbSNP:rs2363198). VAR_046069 2363198

Database cross-references

UniProt: P46734
Ensembl: ENST00000316920
Ensembl: ENST00000342679
Ensembl: ENST00000361818
MIM: 602315
neXtProt: NX_P46734
Antibodypedia: P46734 (may not find the protein thus also not any antibody)
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RBCC Red Blood Cell Collection

MP2K3_HUMAN

Genetic variants

Database cross-references

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