MP2K5_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: MAP2K5 , MEK5, MKK5, PRKMK5
Protein names and data: MP2K5_HUMAN , Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPKK 5; 2.7.12.2 , MAPK/ERK kinase 5; MEK 5 Lenght: 448 a.a.
Mass: 50112 Da
fasta formatted sequence
Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Tissue specificity: Expressed in many adult tissues. Abundant in heart and skeletal muscle.

Genetic variants

Database cross-references

UniProt: Q13163
Ensembl: ENST00000178640
Ensembl: ENST00000354498
Ensembl: ENST00000395476
MIM: 602520
neXtProt: NX_Q13163
Antibodypedia: Q13163 (may not find the protein thus also not any antibody)
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