RBCC Red Blood Cell Collection

MRP1_HUMAN

Source: hRBCD ; ID: IPI00008338
PM19886704
PM23856902
PM22954596
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: ABCC1 , MRP, MRP1
Protein names and data: MRP1_HUMAN , Multidrug resistance-associated protein 1 , ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter Lenght: 1531 a.a.
Mass: 171591 Da
fasta formatted sequence
Function: Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Cellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Lung, testis and peripheral blood mononuclear cells.

Genetic variants

43 - 43 C -> S (in dbSNP:rs41395947). VAR_013317 41395947
73 - 73 T -> I (in dbSNP:rs41494447). VAR_013318 41494447
117 - 117 M -> T. VAR_013319
433 - 433 R -> S (in dbSNP:rs60782127). VAR_013320 60782127
633 - 633 R -> Q (in dbSNP:rs112282109). VAR_011488 112282109
671 - 671 G -> V (no effect on leukotriene C4 and estradiol glucuronide transport; dbSNP:rs45511401). VAR_011489 45511401
723 - 723 R -> Q (in dbSNP:rs4148356). VAR_013321 4148356
861 - 861 A -> T (in dbSNP:rs45517537). VAR_055384 45517537
1047 - 1047 C -> S (in dbSNP:rs13337489). VAR_055385 13337489
1058 - 1058 R -> Q (in dbSNP:rs41410450). VAR_013322 41410450
1146 - 1146 V -> I (in dbSNP:rs28706727). VAR_055386 28706727
1512 - 1512 S -> L. VAR_013323

Database cross-references

UniProt: P33527
Ensembl: ENST00000345148
Ensembl: ENST00000346370
Ensembl: ENST00000349029
Ensembl: ENST00000351154
Ensembl: ENST00000399408
Ensembl: ENST00000399410
MIM: 158343
neXtProt: NX_P33527
Antibodypedia: P33527 (may not find the protein thus also not any antibody)
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