MRP4_HUMAN
Source:
hRBCD
; ID:
IPI00006675
PM19886704
PM23856902
BSc_CH
PM22954596
Marked as 'Integral membrane protein'
Confidence:
high (present in two of the MS resources)
Search PubMed for
(RBC AND this entry)
Gene names:
ABCC4
, MRP4
Protein names and data:
MRP4_HUMAN
, Multidrug resistance-associated protein 4
, ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B
Lenght: 1325 a.a.
Mass: 149527 Da
fasta formatted sequence
Function:
May be an organic anion pump relevant to cellular detoxification.
Cellular location:
Membrane; Multi-pass membrane protein.
Tissue specificity:
Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.
Genetic variants
18 - 18
L -> I (in dbSNP:rs11568681). VAR_046445
11568681
78 - 78
P -> A (in dbSNP:rs11568689). VAR_029121
11568689
171 - 171
C -> G (in dbSNP:rs4148460). VAR_046446
4148460
184 - 184
M -> T (in dbSNP:rs45454092). VAR_020241
45454092
187 - 187
G -> W (transport properties comparable to wild-type; dbSNP:rs11568658). VAR_020242
11568658
293 - 293
K -> E (in dbSNP:rs11568684). VAR_046447
11568684
304 - 304
K -> N (transport properties comparable to wild-type; dbSNP:rs2274407). VAR_022072
2274407
356 - 356
T -> M (in dbSNP:rs11568701). VAR_046448
11568701
403 - 403
P -> L (in dbSNP:rs11568705). VAR_029122
11568705
487 - 487
G -> E (transport properties comparable to wild-type; dbSNP:rs11568668). VAR_029123
11568668
498 - 498
K -> E (in dbSNP:rs11568669). VAR_020243
11568669
556 - 556
Y -> C (40% reduced expression level compared to wild-type; higher transport of 9-(2-phosphonyl-methoxyethyl) adenine than wild-type). VAR_045684
625 - 625
I -> M (in dbSNP:rs11568699). VAR_029124
11568699
667 - 667
P -> L (in dbSNP:rs11568697). VAR_029125
11568697
744 - 744
M -> V (in dbSNP:rs9282570). VAR_020244
9282570
757 - 757
E -> K (10% reduced expression level compared to wild-type; transport properties comparable to wild-type; dbSNP:rs3765534). VAR_022073
3765534
776 - 776
V -> I (20% reduced expression level compared to wild-type; significant lower activity in 6-mercaptopurine transport than wild-type). VAR_045685
820 - 820
R -> I (transport properties comparable to wild-type; dbSNP:rs11568659). VAR_045686
11568659
854 - 854
V -> F (transport properties comparable to wild-type; dbSNP:rs11568694). VAR_045687
11568694
860 - 860
V -> M (in dbSNP:rs45477596). VAR_020245
45477596
866 - 866
I -> V (transport properties comparable to wild-type; dbSNP:rs139970608). VAR_045688
139970608
900 - 900
V -> L (in dbSNP:rs45504892). VAR_020246
45504892
1142 - 1142
T -> M (10% reduced expression level compared to wild-type; transport properties comparable to wild-type; dbSNP:rs11568644). VAR_029126
11568644
Database cross-references
UniProt:
O15439
Ensembl:
ENST00000376887
Ensembl:
ENST00000412704
Ensembl:
ENST00000431522
MIM:
605250
neXtProt:
NX_O15439
Antibodypedia:
O15439
(may not find the protein thus also not any antibody)
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