MVP_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: MVP , LRP
Protein names and data: MVP_HUMAN , Major vault protein; MVP , Lung resistance-related protein Lenght: 893 a.a.
Mass: 99327 Da
fasta formatted sequence
Function: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Cellular location: Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
Tissue specificity: Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.

Genetic variants

Database cross-references

UniProt: Q14764
Ensembl: ENST00000357402
Ensembl: ENST00000395353
MIM: 605088
neXtProt: NX_Q14764
Antibodypedia: Q14764 (may not find the protein thus also not any antibody)
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