MYH10_HUMAN

Source: PM19886704
PM23856902
BSc_CH
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: MYH10
Protein names and data: MYH10_HUMAN , Myosin-10 , Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; Non-muscle myosin heavy chain B; NMMHC-B; Non-muscle myosin heavy chain IIb; NMMHC II-b; NMMHC-IIB Lenght: 1976 a.a.
Mass: 228999 Da
fasta formatted sequence
Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.
Cellular location: Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells.
Tissue specificity: Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.

Database cross-references

UniProt: P35580
Ensembl: ENST00000269243
Ensembl: ENST00000360416
Ensembl: ENST00000396239
MIM: 160776
neXtProt: NX_P35580
Antibodypedia: P35580 (may not find the protein thus also not any antibody)
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