Source: BSc_CH
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: MYO1G , HA2
Protein names and data: MYO1G_HUMAN , Unconventional myosin-Ig; Minor histocompatibility antigen HA-2; mHag HA-2 Lenght: 1018 a.a.
Mass: 116442 Da
fasta formatted sequence

Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Precursor of the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201.
Cellular location: Cell membrane; Peripheral membrane protein. Note=Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles.
Tissue specificity: Specifically expressed in hematopoietic cells.

Genetic variants

Database cross-references

UniProt: B0I1T2
Ensembl: ENST00000258787
MIM: 613445
neXtProt: NX_B0I1T2
Antibodypedia: B0I1T2 (may not find the protein thus also not any antibody)
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