NACA_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NACA , HSD48
Protein names and data: NACA_HUMAN , Nascent polypeptide-associated complex subunit alpha; NAC-alpha , Alpha-NAC; Hom s 2 Lenght: 215 a.a.
Mass: 23384 Da
fasta formatted sequence
Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
Cellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also found in nucleus.
Tissue specificity: Ubiquitously expressed.

Database cross-references

UniProt: Q13765
Ensembl: ENST00000356769
Ensembl: ENST00000393891
Ensembl: ENST00000546392
Ensembl: ENST00000552540
MIM: 601234
neXtProt: NX_Q13765
Antibodypedia: Q13765 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.