NAMPT_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NAMPT , PBEF, PBEF1
Protein names and data: NAMPT_HUMAN , Nicotinamide phosphoribosyltransferase; NAmPRTase; Nampt; 2.4.2.12 , Pre-B-cell colony-enhancing factor 1; Pre-B cell-enhancing factor; Visfatin Lenght: 491 a.a.
Mass: 55521 Da
fasta formatted sequence
Function: Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma.
Catalytic activity: Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate.
Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and nicotinamide: step 1/1.
Cellular location: Nucleus. Cytoplasm (By similarity). Secreted. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.
Tissue specificity: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.

Genetic variants

Database cross-references

UniProt: P43490
Ensembl: ENST00000222553
Ensembl: ENST00000354289
MIM: 608764
neXtProt: NX_P43490
Antibodypedia: P43490 (may not find the protein thus also not any antibody)
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