RBCC

NAR4_HUMAN

Source: hRBCD ; ID: IPI00004065
PM23856902
BGMUT ; ID: dombrock
BSc_CH
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)
Gene names: ART4 , DO, DOK1
Protein names and data: NAR4_HUMAN , Ecto-ADP-ribosyltransferase 4; 2.4.2.31 , ADP-ribosyltransferase C2 and C3 toxin-like 4; ARTC4; Dombrock blood group carrier molecule; Mono(ADP-ribosyl)transferase 4; NAD(P)(+)--arginine ADP-ribosyltransferase 4; CD297; Flags: Precursor Lenght: 314 a.a.
Mass: 35878 Da
fasta formatted sequence
Catalytic activity: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.
Cellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Tissue specificity: Expressed in spleen and T-cells.

Genetic variants

DO is responsible for the Dombrock blood group system. The molecular basis of the Do(a)/Do(b) blood group antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is also responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)].

108 - 108 G -> V (in Hy1 and Hy2; dbSNP:rs28362797). VAR_013707 28362797
117 - 117 T -> I (in Jo(a); dbSNP:rs28362798). VAR_013708 28362798
135 - 135 D -> E (in dbSNP:rs28362799). VAR_022266 28362799
189 - 189 T -> M (in dbSNP:rs28362800). VAR_022267 28362800
265 - 265 N -> D (in Do(b), Hy1 and Hy2; dbSNP:rs11276). VAR_013709 11276
300 - 300 L -> V (in Hy1; dbSNP:rs3088190). VAR_013710 3088190

Database cross-references

UniProt: Q93070
Ensembl: ENST00000228936
MIM: 110600
neXtProt: NX_Q93070
Antibodypedia: Q93070 (may not find the protein thus also not any antibody)
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RBCC Red Blood Cell Collection

NAR4_HUMAN

Genetic variants

Database cross-references

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