Source: hRBCD ; ID: IPI00004065
BGMUT ; ID: dombrock
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: ART4 , DO, DOK1
Protein names and data: NAR4_HUMAN , Ecto-ADP-ribosyltransferase 4; , ADP-ribosyltransferase C2 and C3 toxin-like 4; ARTC4; Dombrock blood group carrier molecule; Mono(ADP-ribosyl)transferase 4; NAD(P)(+)--arginine ADP-ribosyltransferase 4; CD297; Flags: Precursor Lenght: 314 a.a.
Mass: 35878 Da
fasta formatted sequence

Catalytic activity: NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.
Cellular location: Cell membrane; Lipid-anchor, GPI-anchor.
Tissue specificity: Expressed in spleen and T-cells.

Genetic variants

DO is responsible for the Dombrock blood group system. The molecular basis of the Do(a)/Do(b) blood group antigen is a single variation in position 265; Asn-265 corresponds to Do(a) and Asp-265 to Do(b). It is also responsible for the antigens Gregory [Gy(a)], Holley [Hy] and Joseph [Jo(a)].

Database cross-references

UniProt: Q93070
Ensembl: ENST00000228936
MIM: 110600
neXtProt: NX_Q93070
Antibodypedia: Q93070 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.