NC2A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: DRAP1
Protein names and data: NC2A_HUMAN , Dr1-associated corepressor , Dr1-associated protein 1; Negative cofactor 2-alpha; NC2-alpha Lenght: 205 a.a.
Mass: 22350 Da
fasta formatted sequence
Function: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Cellular location: Nucleus (Potential).
Tissue specificity: Ubiquitous. Highly expressed in adult testis, heart, skeletal muscle, pancreas and brain, and in fetal brain, liver and kidney.

Database cross-references

UniProt: Q14919
Ensembl: ENST00000312515
MIM: 602289
neXtProt: NX_Q14919
Antibodypedia: Q14919 (may not find the protein thus also not any antibody)
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