NC2B_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: DR1
Protein names and data: NC2B_HUMAN , Protein Dr1 , Down-regulator of transcription 1; Negative cofactor 2-beta; NC2-beta; TATA-binding protein-associated phosphoprotein Lenght: 176 a.a.
Mass: 19444 Da
fasta formatted sequence
Function: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Cellular location: Nucleus.

Genetic variants

Database cross-references

UniProt: Q01658
Ensembl: ENST00000370267
Ensembl: ENST00000370272
MIM: 601482
neXtProt: NX_Q01658
Antibodypedia: Q01658 (may not find the protein thus also not any antibody)
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