NCEH1_HUMAN

Source: hRBCD ; ID: IPI00002230
PM19886704
PM23856902
BSc_CH
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: NCEH1 , AADACL1, KIAA1363
Protein names and data: NCEH1_HUMAN , Neutral cholesterol ester hydrolase 1; NCEH; 3.1.1.- , Arylacetamide deacetylase-like 1 Lenght: 408 a.a.
Mass: 45808 Da
fasta formatted sequence
Function: Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration.
Cellular location: Membrane; Single-pass type II membrane protein (Probable). Microsome (By similarity).
Tissue specificity: Expressed in monocyte-derived macrophages. Up- regulated in invasive melanoma and breast carcinoma cell lines.

Genetic variants

Database cross-references

UniProt: Q6PIU2
Ensembl: ENST00000475381
Ensembl: ENST00000543711
MIM: 613234
neXtProt: NX_Q6PIU2
Antibodypedia: Q6PIU2 (may not find the protein thus also not any antibody)
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