NCS1_HUMAN

Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NCS1 , FLUP, FREQ
Protein names and data: NCS1_HUMAN , Neuronal calcium sensor 1; NCS-1 , Frequenin homolog; Frequenin-like protein; Frequenin-like ubiquitous protein Lenght: 190 a.a.
Mass: 21879 Da
fasta formatted sequence
Function: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity).
Cellular location: Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.

Database cross-references

UniProt: P62166
Ensembl: ENST00000372398
Ensembl: ENST00000458469
Ensembl: ENST00000599518
Ensembl: ENST00000601889
MIM: 603315
neXtProt: NX_P62166
Antibodypedia: P62166 (may not find the protein thus also not any antibody)
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