NDKA_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NME1 , NDPKA, NM23
Protein names and data: NDKA_HUMAN , Nucleoside diphosphate kinase A; NDK A; NDP kinase A; 2.7.4.6 , Granzyme A-activated DNase; GAAD; Metastasis inhibition factor nm23; Tumor metastatic process-associated protein; nm23-H1 Lenght: 152 a.a.
Mass: 17149 Da
fasta formatted sequence
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cellular location: Cytoplasm. Nucleus. Note=Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed.

Genetic variants

Database cross-references

UniProt: P15531
Ensembl: ENST00000013034
Ensembl: ENST00000336097
Ensembl: ENST00000393196
MIM: 156490
neXtProt: NX_P15531
Antibodypedia: P15531 (may not find the protein thus also not any antibody)
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