NDKB_HUMAN

Source: hRBCD ; ID: IPI00026260
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: NME2 , NM23B
Protein names and data: NDKB_HUMAN , Nucleoside diphosphate kinase B; NDK B; NDP kinase B; 2.7.4.6 , C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; 2.7.13.3; nm23-H2 Lenght: 152 a.a.
Mass: 17298 Da
fasta formatted sequence
Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Catalytic activity: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. ATP + protein L-histidine = ADP + protein N- phospho-L-histidine.
Cellular location: Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.
Tissue specificity: Ubiquitously expressed.

Database cross-references

UniProt: P22392
Ensembl: ENST00000393193
Ensembl: ENST00000393198
MIM: 156491
neXtProt: NX_P22392
Antibodypedia: P22392 (may not find the protein thus also not any antibody)
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