NDUS1_HUMAN

Source: BSc_CH
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: NDUFS1
Protein names and data: NDUS1_HUMAN , NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; 1.6.5.3; 1.6.99.3 , Complex I-75kD; CI-75kD; Flags: Precursor Lenght: 727 a.a.
Mass: 79468 Da
fasta formatted sequence
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.
Catalytic activity: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out). NADH + acceptor = NAD(+) + reduced acceptor.
Disease:
Cellular location: Mitochondrion inner membrane.

Genetic variants

Database cross-references

UniProt: P28331
Ensembl: ENST00000233190
Ensembl: ENST00000423725
Ensembl: ENST00000432169
Ensembl: ENST00000440274
Ensembl: ENST00000449699
Ensembl: ENST00000455934
MIM: 157655
MIM: 252010
neXtProt: NX_P28331
Antibodypedia: P28331 (may not find the protein thus also not any antibody)
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