NED4L_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NEDD4L , KIAA0439, NEDL3
Protein names and data: NED4L_HUMAN , E3 ubiquitin-protein ligase NEDD4-like; 6.3.2.- , NEDD4.2; Nedd4-2 Lenght: 975 a.a.
Mass: 111932 Da
fasta formatted sequence
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Cytoplasm. Note=May be recruited to exosomes by NDFIP1.
Tissue specificity: Ubiquitously expressed, with highest levels in prostate, pancreas and kidney.

Genetic variants

Database cross-references

UniProt: Q96PU5
Ensembl: ENST00000256830
Ensembl: ENST00000356462
Ensembl: ENST00000357895
Ensembl: ENST00000382850
Ensembl: ENST00000400345
Ensembl: ENST00000431212
Ensembl: ENST00000435432
Ensembl: ENST00000456173
Ensembl: ENST00000456986
Ensembl: ENST00000586263
MIM: 606384
neXtProt: NX_Q96PU5
Antibodypedia: Q96PU5 (may not find the protein thus also not any antibody)
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