NEDD4_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NEDD4 , KIAA0093, NEDD4-1 , PIG53
Protein names and data: NEDD4_HUMAN , E3 ubiquitin-protein ligase NEDD4; 6.3.2.- , Cell proliferation-inducing gene 53 protein; Neural precursor cell expressed developmentally down-regulated protein 4; NEDD-4 Lenght: 1319 a.a.
Mass: 149114 Da
fasta formatted sequence
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR- 2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1.

Genetic variants

Database cross-references

UniProt: P46934
Ensembl: ENST00000338963
Ensembl: ENST00000435532
Ensembl: ENST00000506154
Ensembl: ENST00000508342
MIM: 602278
neXtProt: NX_P46934
Antibodypedia: P46934 (may not find the protein thus also not any antibody)
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