NFE2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NFE2
Protein names and data: NFE2_HUMAN , Transcription factor NF-E2 45 kDa subunit , Leucine zipper protein NF-E2; Nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2 Lenght: 373 a.a.
Mass: 41473 Da
fasta formatted sequence
Function: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
Cellular location: Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH.
Tissue specificity: Expressed in hematopoietic cells and also in colon and testis.

Database cross-references

UniProt: Q16621
Ensembl: ENST00000312156
Ensembl: ENST00000435572
Ensembl: ENST00000540264
Ensembl: ENST00000553070
MIM: 601490
neXtProt: NX_Q16621
Antibodypedia: Q16621 (may not find the protein thus also not any antibody)
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