NFX1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NFX1 , NFX2
Protein names and data: NFX1_HUMAN , Transcriptional repressor NF-X1; 6.3.2.- , Nuclear transcription factor, X box-binding protein 1 Lenght: 1120 a.a.
Mass: 124395 Da
fasta formatted sequence
Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
Cellular location: Nucleus.

Genetic variants

Database cross-references

UniProt: Q12986
Ensembl: ENST00000318524
Ensembl: ENST00000379521
Ensembl: ENST00000379540
MIM: 603255
neXtProt: NX_Q12986
Antibodypedia: Q12986 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.