Source: hRBCD ; ID: IPI00021983
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: NCSTN , KIAA0253 , UNQ1874/PRO4317
Protein names and data: NICA_HUMAN , Nicastrin; Flags: Precursor Lenght: 709 a.a.
Mass: 78411 Da
fasta formatted sequence

Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Cellular location: Membrane; Single-pass type I membrane protein (Potential). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue specificity: Widely expressed.

Genetic variants

Database cross-references

UniProt: Q92542
Ensembl: ENST00000294785
Ensembl: ENST00000368063
Ensembl: ENST00000392212
MIM: 142690
MIM: 605254
neXtProt: NX_Q92542
Antibodypedia: Q92542 (may not find the protein thus also not any antibody)
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