NIT1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NIT1
Protein names and data: NIT1_HUMAN , Nitrilase homolog 1; 3.5.-.- Lenght: 327 a.a.
Mass: 35896 Da
fasta formatted sequence
Function: Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity).
Cellular location: Cytoplasm. Mitochondrion (By similarity).
Tissue specificity: Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

Database cross-references

UniProt: Q86X76
Ensembl: ENST00000368007
Ensembl: ENST00000368009
Ensembl: ENST00000392190
MIM: 604618
neXtProt: NX_Q86X76
Antibodypedia: Q86X76 (may not find the protein thus also not any antibody)
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