NMNA3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NMNAT3 , FKSG76
Protein names and data: NMNA3_HUMAN , Nicotinamide mononucleotide adenylyltransferase 3; NMN adenylyltransferase 3 , Nicotinate-nucleotide adenylyltransferase 3; NaMN adenylyltransferase 3; 2.7.7.18; Pyridine nucleotide adenylyltransferase 3; PNAT-3; 2.7.7.1 Lenght: 252 a.a.
Mass: 28322 Da
fasta formatted sequence
Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.
Catalytic activity: ATP + nicotinamide ribonucleotide = diphosphate + NAD(+). ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+).
Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
Cellular location: Mitochondrion.
Tissue specificity: Expressed in lung and spleen with lower levels in placenta and kidney.

Database cross-references

UniProt: Q96T66
Ensembl: ENST00000296202
Ensembl: ENST00000339837
Ensembl: ENST00000406164
Ensembl: ENST00000413939
MIM: 608702
neXtProt: NX_Q96T66
Antibodypedia: Q96T66 (may not find the protein thus also not any antibody)
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