NOD2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: NOD2 , CARD15, IBD1
Protein names and data: NOD2_HUMAN , Nucleotide-binding oligomerization domain-containing protein 2 , Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1 Lenght: 1040 a.a.
Mass: 115283 Da
fasta formatted sequence

Function: Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor- interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response.
Disease:
Cellular location: Cytoplasm.
Tissue specificity: Monocytes-specific.

Genetic variants

Database cross-references

UniProt: Q9HC29
Ensembl: ENST00000300589
MIM: 186580
MIM: 266600
MIM: 605956
MIM: 609464
neXtProt: NX_Q9HC29
Antibodypedia: Q9HC29 (may not find the protein thus also not any antibody)
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