NPL_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NPL , C1orf13
Protein names and data: NPL_HUMAN , N-acetylneuraminate lyase; NALase; 4.1.3.3 , N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Sialate-pyruvate lyase; Sialic acid aldolase; Sialic acid lyase Lenght: 320 a.a.
Mass: 35163 Da
fasta formatted sequence
Function: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).
Catalytic activity: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.
Pathway: Amino-sugar metabolism; N-acetylneuraminate degradation.
Cellular location: Cytoplasm (By similarity).
Tissue specificity: Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.

Database cross-references

UniProt: Q9BXD5
Ensembl: ENST00000258317
Ensembl: ENST00000367552
Ensembl: ENST00000367553
Ensembl: ENST00000367554
Ensembl: ENST00000367555
MIM: 611412
neXtProt: NX_Q9BXD5
Antibodypedia: Q9BXD5 (may not find the protein thus also not any antibody)
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