NTKL_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: SCYL1 , CVAK90, GKLP, NTKL, TAPK, TEIF, TRAP , HT019
Protein names and data: NTKL_HUMAN , N-terminal kinase-like protein , Coated vesicle-associated kinase of 90 kDa; SCY1-like protein 1; Telomerase regulation-associated protein; Telomerase transcriptional element-interacting factor; Teratoma-associated tyrosine kinase Lenght: 808 a.a.
Mass: 89631 Da
fasta formatted sequence
Function: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.
Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner. Isoform 1: Cytoplasm. Note=Cytoplasmic throughout the cell cycle. Isoform 2: Cytoplasm. Note=Cytoplasmic throughout the cell cycle. Isoform 3: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner. Isoform 6: Nucleus.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q96KG9
Ensembl: ENST00000270176
Ensembl: ENST00000279270
Ensembl: ENST00000420247
Ensembl: ENST00000527630
Ensembl: ENST00000533862
MIM: 607982
neXtProt: NX_Q96KG9
Antibodypedia: Q96KG9 (may not find the protein thus also not any antibody)
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