NUAK1_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NUAK1 , ARK5, KIAA0537, OMPHK1
Protein names and data: NUAK1_HUMAN , NUAK family SNF1-like kinase 1; 2.7.11.1 , AMPK-related protein kinase 5; ARK5; Omphalocele kinase 1 Lenght: 661 a.a.
Mass: 74305 Da
fasta formatted sequence
Function: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser- 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cellular location: Nucleus. Cytoplasm.
Tissue specificity: Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines.

Genetic variants

Database cross-references

UniProt: O60285
Ensembl: ENST00000261402
MIM: 608130
neXtProt: NX_O60285
Antibodypedia: O60285 (may not find the protein thus also not any antibody)
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