NUCB2_HUMAN

Source: PM23856902
BSc_CH
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: NUCB2 , NEFA
Protein names and data: NUCB2_HUMAN , Nucleobindin-2 , DNA-binding protein NEFA; Gastric cancer antigen Zg4; Prepronesfatin; Nesfatin-1; Flags: Precursor Lenght: 420 a.a.
Mass: 50196 Da
fasta formatted sequence
Function: Calcium-binding protein. May have a role in calcium homeostasis. Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity).
Cellular location: Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted. Endoplasmic reticulum (By similarity). Nucleus envelope (By similarity). Note=Golgi retention is mediated by its N-terminal region. Nesfatin-1: Secreted.
Tissue specificity: Predominantly expressed in spleen, testis and normal stomach.

Genetic variants

Deletion of Gln-402 is frequent.

Database cross-references

UniProt: P80303
Ensembl: ENST00000323688
Ensembl: ENST00000529010
MIM: 608020
neXtProt: NX_P80303
Antibodypedia: P80303 (may not find the protein thus also not any antibody)
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