NUDT4_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NUDT4 , DIPP2, KIAA0487 , HDCMB47P
Protein names and data: NUDT4_HUMAN , Diphosphoinositol polyphosphate phosphohydrolase 2; DIPP-2; 3.6.1.52 , Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; 3.6.1.-; Nucleoside diphosphate-linked moiety X motif 4; Nudix motif 4 Lenght: 180 a.a.
Mass: 20306 Da
fasta formatted sequence
Function: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
Catalytic activity: Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.
Cellular location: Cytoplasm.
Tissue specificity: Expressed in heart and, at lower level in skeletal muscle, pancreas and kidney.

Database cross-references

UniProt: Q9NZJ9
Ensembl: ENST00000337179
Ensembl: ENST00000415493
Ensembl: ENST00000547014
Ensembl: ENST00000548662
Ensembl: ENST00000549992
MIM: 609229
neXtProt: NX_Q9NZJ9
Antibodypedia: Q9NZJ9 (may not find the protein thus also not any antibody)
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