NUP50_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: NUP50 , NPAP60L , PRO1146
Protein names and data: NUP50_HUMAN , Nuclear pore complex protein Nup50 , 50 kDa nucleoporin; Nuclear pore-associated protein 60 kDa-like; Nucleoporin Nup50 Lenght: 468 a.a.
Mass: 50144 Da
fasta formatted sequence
Function: Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.
Cellular location: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side (By similarity). Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase.
Tissue specificity: Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.

Database cross-references

UniProt: Q9UKX7
Ensembl: ENST00000347635
Ensembl: ENST00000396096
Ensembl: ENST00000407019
MIM: 604646
neXtProt: NX_Q9UKX7
Antibodypedia: Q9UKX7 (may not find the protein thus also not any antibody)
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