OLFM4_HUMAN

Source: PM23856902
BSc_CH
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: OLFM4 , GW112 , UNQ362/PRO698
Protein names and data: OLFM4_HUMAN , Olfactomedin-4; OLM4 , Antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein; hGC-1; hOLfD; Flags: Precursor Lenght: 510 a.a.
Mass: 57280 Da
fasta formatted sequence
Function: May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
Cellular location: Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901).
Tissue specificity: Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.

Genetic variants

Database cross-references

UniProt: Q6UX06
Ensembl: ENST00000219022
MIM: 614061
neXtProt: NX_Q6UX06
Antibodypedia: Q6UX06 (may not find the protein thus also not any antibody)
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