OTU1_HUMAN

Source: hRBCD ; ID: IPI00183503
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: YOD1 , DUBA8, HIN7, OTUD2 , PRO0907
Protein names and data: OTU1_HUMAN , Ubiquitin thioesterase OTU1; 3.4.19.12 , DUBA-8; HIV-1-induced protease 7; HIN-7; HsHIN7; OTU domain-containing protein 2 Lenght: 348 a.a.
Mass: 38322 Da
fasta formatted sequence
Function: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Database cross-references

UniProt: Q5VVQ6
Ensembl: ENST00000315927
Ensembl: ENST00000367084
Ensembl: ENST00000391927
MIM: 612023
neXtProt: NX_Q5VVQ6
Antibodypedia: Q5VVQ6 (may not find the protein thus also not any antibody)
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