OTUD5_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: OTUD5
Protein names and data: OTUD5_HUMAN , OTU domain-containing protein 5; 3.4.19.12 , Deubiquitinating enzyme A; DUBA Lenght: 571 a.a.
Mass: 60626 Da
fasta formatted sequence
Function: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro).
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Tissue specificity: Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes.

Database cross-references

UniProt: Q96G74
Ensembl: ENST00000156084
Ensembl: ENST00000428668
Ensembl: ENST00000594822
Ensembl: ENST00000597676
MIM: 300713
neXtProt: NX_Q96G74
Antibodypedia: Q96G74 (may not find the protein thus also not any antibody)
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