P85A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: PIK3R1 , GRB1
Protein names and data: P85A_HUMAN , Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha , Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha Lenght: 724 a.a.
Mass: 83598 Da
fasta formatted sequence

Function: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.
Disease:
Tissue specificity: Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).

Genetic variants

Database cross-references

UniProt: P27986
Ensembl: ENST00000274335
Ensembl: ENST00000320694
Ensembl: ENST00000336483
Ensembl: ENST00000396611
Ensembl: ENST00000521381
Ensembl: ENST00000521657
Ensembl: ENST00000523872
MIM: 171833
MIM: 269880
MIM: 615214
neXtProt: NX_P27986
Antibodypedia: P27986 (may not find the protein thus also not any antibody)
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