PA24A_HUMAN

Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PLA2G4A , CPLA2, PLA2G4
Protein names and data: PA24A_HUMAN , Cytosolic phospholipase A2; cPLA2 , Phospholipase A2 group IVA; Phospholipase A2; 3.1.1.4; Phosphatidylcholine 2-acylhydrolase; Lysophospholipase; 3.1.1.5 Lenght: 749 a.a.
Mass: 85239 Da
fasta formatted sequence
Function: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Catalytic activity: Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Cellular location: Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.
Tissue specificity: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.

Genetic variants

Database cross-references

UniProt: P47712
Ensembl: ENST00000367466
MIM: 600522
neXtProt: NX_P47712
Antibodypedia: P47712 (may not find the protein thus also not any antibody)
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