PA2G4_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PA2G4 , EBP1
Protein names and data: PA2G4_HUMAN , Proliferation-associated protein 2G4 , Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1 Lenght: 394 a.a.
Mass: 43787 Da
fasta formatted sequence
Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity).
Cellular location: Cytoplasm. Nucleus, nucleolus. Note=Tranlocates to the nucleus upon treatment with HRG.
Tissue specificity: Expressed in several cell lines tested, including primary and transformed cell lines.

Database cross-references

UniProt: Q9UQ80
Ensembl: ENST00000303305
MIM: 602145
neXtProt: NX_Q9UQ80
Antibodypedia: Q9UQ80 (may not find the protein thus also not any antibody)
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