PAAF1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PAAF1 , WDR71
Protein names and data: PAAF1_HUMAN , Proteasomal ATPase-associated factor 1 , Protein G-16; WD repeat-containing protein 71 Lenght: 392 a.a.
Mass: 42190 Da
fasta formatted sequence
Function: Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.
Tissue specificity: Ubiquitously expressed, with highest levels in kidney, brain and testis.

Genetic variants

Database cross-references

UniProt: Q9BRP4
Ensembl: ENST00000310571
Ensembl: ENST00000376384
Ensembl: ENST00000535604
Ensembl: ENST00000536003
Ensembl: ENST00000541951
Ensembl: ENST00000544552
neXtProt: NX_Q9BRP4
Antibodypedia: Q9BRP4 (may not find the protein thus also not any antibody)
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