PABP1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PABPC1 , PAB1, PABP1, PABPC2
Protein names and data: PABP1_HUMAN , Polyadenylate-binding protein 1; PABP-1; Poly(A)-binding protein 1 Lenght: 636 a.a.
Mass: 70671 Da
fasta formatted sequence
Function: Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.
Cellular location: Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the cytoplasm and the nucleus.
Tissue specificity: Ubiquitous.

Database cross-references

UniProt: P11940
Ensembl: ENST00000318607
MIM: 604679
neXtProt: NX_P11940
Antibodypedia: P11940 (may not find the protein thus also not any antibody)
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