PACN2_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PACSIN2
Protein names and data: PACN2_HUMAN , Protein kinase C and casein kinase substrate in neurons protein 2 , Syndapin-2; Syndapin-II Lenght: 486 a.a.
Mass: 55739 Da
fasta formatted sequence
Function: Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
Cellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection (By similarity). Membrane, caveola. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
Tissue specificity: Widely expressed.

Genetic variants

Database cross-references

UniProt: Q9UNF0
Ensembl: ENST00000263246
Ensembl: ENST00000337959
Ensembl: ENST00000402229
Ensembl: ENST00000403744
Ensembl: ENST00000407585
MIM: 604960
neXtProt: NX_Q9UNF0
Antibodypedia: Q9UNF0 (may not find the protein thus also not any antibody)
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