PAIP1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PAIP1
Protein names and data: PAIP1_HUMAN , Polyadenylate-binding protein-interacting protein 1; PABP-interacting protein 1; PAIP-1; Poly(A)-binding protein-interacting protein 1 Lenght: 479 a.a.
Mass: 53525 Da
fasta formatted sequence
Function: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.
Cellular location: Cytoplasm (Probable).

Database cross-references

UniProt: Q9H074
Ensembl: ENST00000306846
Ensembl: ENST00000338972
Ensembl: ENST00000436644
MIM: 605184
neXtProt: NX_Q9H074
Antibodypedia: Q9H074 (may not find the protein thus also not any antibody)
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