PARN_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PARN , DAN
Protein names and data: PARN_HUMAN , Poly(A)-specific ribonuclease PARN; 3.1.13.4 , Deadenylating nuclease; Deadenylation nuclease; Polyadenylate-specific ribonuclease Lenght: 639 a.a.
Mass: 73451 Da
fasta formatted sequence
Function: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization.
Catalytic activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Cellular location: Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Some nuclear fraction is nucleolar.
Tissue specificity: Ubiquitous.

Database cross-references

UniProt: O95453
Ensembl: ENST00000341484
Ensembl: ENST00000420015
Ensembl: ENST00000437198
MIM: 604212
neXtProt: NX_O95453
Antibodypedia: O95453 (may not find the protein thus also not any antibody)
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