PBX1_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PBX1 , PRL
Protein names and data: PBX1_HUMAN , Pre-B-cell leukemia transcription factor 1 , Homeobox protein PBX1; Homeobox protein PRL Lenght: 430 a.a.
Mass: 46626 Da
fasta formatted sequence
Function: Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).
Disease:
Cellular location: Nucleus (By similarity).
Tissue specificity: Expressed in all tissues except in cells of the B and T lineage.

Genetic variants

Database cross-references

UniProt: P40424
Ensembl: ENST00000367897
Ensembl: ENST00000401534
Ensembl: ENST00000420696
Ensembl: ENST00000540236
MIM: 176310
neXtProt: NX_P40424
Antibodypedia: P40424 (may not find the protein thus also not any antibody)
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