PCBP2_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PCBP2
Protein names and data: PCBP2_HUMAN , Poly(rC)-binding protein 2 , Alpha-CP2; Heterogeneous nuclear ribonucleoprotein E2; hnRNP E2 Lenght: 365 a.a.
Mass: 38580 Da
fasta formatted sequence
Function: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation.
Cellular location: Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
Tissue specificity: Detected in all tissues examined.

Database cross-references

UniProt: Q15366
Ensembl: ENST00000359282
Ensembl: ENST00000359462
Ensembl: ENST00000439930
Ensembl: ENST00000447282
Ensembl: ENST00000546463
Ensembl: ENST00000548933
Ensembl: ENST00000552296
Ensembl: ENST00000603815
MIM: 601210
neXtProt: NX_Q15366
Antibodypedia: Q15366 (may not find the protein thus also not any antibody)
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