PDC10_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PDCD10 , CCM3, TFAR15
Protein names and data: PDC10_HUMAN , Programmed cell death protein 10 , Cerebral cavernous malformations 3 protein; TF-1 cell apoptosis-related protein 15 Lenght: 212 a.a.
Mass: 24702 Da
fasta formatted sequence
Function: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).
Disease:
Cellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Partially co- localizes with endogenous PXN at the leading edges of migrating cells.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q9BUL8
Ensembl: ENST00000392750
Ensembl: ENST00000461494
Ensembl: ENST00000470131
Ensembl: ENST00000473645
Ensembl: ENST00000497056
MIM: 603285
MIM: 609118
neXtProt: NX_Q9BUL8
Antibodypedia: Q9BUL8 (may not find the protein thus also not any antibody)
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