PDC6I_HUMAN

Source: hRBCD ; ID: IPI00246058
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: PDCD6IP , AIP1, ALIX, KIAA1375
Protein names and data: PDC6I_HUMAN , Programmed cell death 6-interacting protein; PDCD6-interacting protein , ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95 Lenght: 868 a.a.
Mass: 96023 Da
fasta formatted sequence
Function: Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.
Cellular location: Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells.

Genetic variants

Database cross-references

UniProt: Q8WUM4
Ensembl: ENST00000307296
Ensembl: ENST00000457054
MIM: 608074
neXtProt: NX_Q8WUM4
Antibodypedia: Q8WUM4 (may not find the protein thus also not any antibody)
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