Source: hRBCD ; ID: IPI00025277
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: PDCD6 , ALG2
Protein names and data: PDCD6_HUMAN , Programmed cell death protein 6 , Apoptosis-linked gene 2 protein; Probable calcium-binding protein ALG-2 Lenght: 191 a.a.
Mass: 21868 Da
fasta formatted sequence

Function: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.
Cellular location: Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Endosome. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.

Genetic variants

Database cross-references

UniProt: O75340
Ensembl: ENST00000264933
Ensembl: ENST00000505221
Ensembl: ENST00000507528
MIM: 601057
neXtProt: NX_O75340
Antibodypedia: O75340 (may not find the protein thus also not any antibody)
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