PDE12_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PDE12
Protein names and data: PDE12_HUMAN , 2',5'-phosphodiesterase 12; 2'-PDE; 2-PDE; 3.1.4.- , Mitochondrial deadenylase; 3.1.13.4; Flags: Precursor Lenght: 609 a.a.
Mass: 67352 Da
fasta formatted sequence
Function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.
Catalytic activity: Exonucleolytic cleavage of poly(A) to 5'-AMP.
Cellular location: Mitochondrion matrix.
Tissue specificity: Ubiquitous.

Genetic variants

Database cross-references

UniProt: Q6L8Q7
Ensembl: ENST00000311180
neXtProt: NX_Q6L8Q7
Antibodypedia: Q6L8Q7 (may not find the protein thus also not any antibody)
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