PEA15_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: PEA15
Protein names and data: PEA15_HUMAN , Astrocytic phosphoprotein PEA-15 , 15 kDa phosphoprotein enriched in astrocytes; Phosphoprotein enriched in diabetes; PED Lenght: 130 a.a.
Mass: 15040 Da
fasta formatted sequence
Function: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Cellular location: Cytoplasm. Note=Associated with microtubules.
Tissue specificity: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.

Database cross-references

UniProt: Q15121
Ensembl: ENST00000360472
MIM: 603434
neXtProt: NX_Q15121
Antibodypedia: Q15121 (may not find the protein thus also not any antibody)
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